Kotoba no Hibiki

have a thick skin 

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A: What’s wrong? You look like down.
B: I failed to get the contract.
A: You mean, about the contract with ABC? That’s too hard for anyone!
B: But…
A: I think you have to have a thick skin in this line of work.

In this situation, what should you say “have a thick skin” in Japanese?

Business

B：この仕事しごとでは打うたれ強づよくないといけないと思おもうよ。

Note: This is not a word-for-word translation.

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A word-for-word translation

B：この仕事しごとでは分厚ぶあつい皮膚ひふを持もってないといけないと思おもうよ。

We don’t say it like above in Japanese, but we have a similar expression; 面つらの皮かわが厚あつい which literally translates ‘You have a thick face skin.’
This expression means ‘brazen’ and has a negative connotation.
So, it’d be better to say 打うたれ強づよい or 神経しんけいが図太ずぶとい in this context.

note: Be careful, as depending on how you say it and the situation, 神経しんけいが図太ずぶとい can have a negative meaning.